Automation and AI for studying cancer behaviour in 3D

IA-BION
IA-BION

The general objective of the project is the automation of studying the behaviour of three-dimensional tumour cell cultures to identify patterns, new variables, and relationships that contribute to understanding cancer behaviour and the overall knowledge of the disease. To achieve such an ambitious general objective, it is necessary to address the following specific objectives: To carry out 3D bioprinting protocols for models suitable for tumour cell culture processes, taking into account the characteristics of the final products to be printed and the printing data and variables for process optimisation and automation. To design systems for monitoring cell cultures based on microscopy images. To collect relevant data to enrich the knowledge of machine learning systems, obtaining indicators associated with historical observations, pattern recognition, and the discovery of new representative variables. To leverage the representations that the system learns automatically to minimise the intervention required by expert human personnel, thereby increasing the capacity and accuracy of analyses.

IA-BION

The IA-BION project focuses on the automation of studying the behaviour of three-dimensional tumour cell cultures to identify patterns and new variables and relationships that contribute to understanding cancer behaviour and the overall knowledge of the disease.

IA-BION

Challenges

The introduction of useful input features to improve the quality of the classification system. In fact, some features may not be suitable for separating the data points.

The acquisition of sufficient unbiased training data for those features, in formats accepted by the system. This data may be in the form of images, text, or any other format.

Solution

Artificial Intelligence system capable of automating the 3D bioprinting process of tumour cell cultures and facilitating the acquisition of reproducible results.

Artificial Intelligence system capable of automating the study of changes in tumour cell cultures based on different variables such as time, the presence of drugs, cell count, or any other significant variable.

Participating entities

Funding entity

FINBA (Fundación para la Investigación y la Innovación Biosanitaria del Principado de Asturias)

Collaborators

IDONIAL